Dried Protein & Stability Blocking

Gold standard

Surmodics immunoassay reagents preserve the conformation and activity of dried proteins coated on a wide range of surfaces, keeping antibodies and antigens at peak performance for long durations. At the same time, the blocking mechanisms in these reagents reduce non-specific binding of interfering proteins to maximize assay sensitivity.

Our immunoassay stabilizers are the gold standard for stability and blocking efficacy. They provide improved assay performance in a one-step process for streamlined manufacturing.

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Signal-to-noise ratios

StabilZyme® HRP, StabilZyme® Protein-Free and StabilZyme® NOBLE stabilizers provide the assay developer a complete set of tools to stabilize different HRP conjugates for long term, in-solution stability.

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Boosting sensitivity. Surmodics Immunoassay Stabilizers provide a choice of blocking mechanisms to achieve optimal signal-to-noise ratios for each assay.

Low standards were run on a commercial PAPP-A sandwich assay using plates coated with StabilBlock®, StabilCoat®, StabilGuard® Immunoassay stabilizers and a competitive commercial blocker. The signal-to-noise ratios were quantified.

Surmodics Immunoassay Stabilizers demonstrated at least 85% retained activity for greater than two years with accelerated stability projections

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Prolonging shelf life. Accelerated stability projections demonstrate at least 85% retained activity for greater than 2 years using Surmodics Immunoassay Stabilizers.

The accelerated stability tests used a rabbit polyclonal IgG ELISA assay to assess each stabilizer. 77 days of accelerated stability testing is equivalent to 2+ years of real-time stability.

DRIED PROTEIN STABILITY

Non-specific binding

StabilBlock® Immunoassay Stabilizer gives assay developers the best possible tool to lower non-specific binding and maximize the signal-to-noise ratios of assays.

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Lowering non-specific binding. StabilBlock® minimizes non-specific binding from the sample matrix and downstream assay components to enable lower detection limits.

A serum assay was constructed to demonstrate lower non-specific binding from the sample matrix. Mouse IgG was passively absorbed onto a plate and blocked. Human serum was incubated, washed and detected using an anti-human IgG (HRP) conjugate. Passive absorption of serum on the plate was quantified.

Longer stability

  • Extended shelf life of dried proteins on various surfaces, including polystyrene plates, latex beads, magnetics particles and nitrocellulose membranes

Increased sensitivity

  • Increased signal-to-noise ratios across the assay range
  • Multiple formulations to optimize lower detection limitsELISA/EIA, ELISpot, RIA, immunoblots and microarrays applications

Negligible backgrounds

  • Elimination of non-specific binding from the sample matrix and other assay components

Ease of manufacture

  • One-step blocking and stabilization process for shorter cycle times
  • ISO 13485/9001 facility for lot-to-lot consistency
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SC01 - StabilCoat® Immunoassay Stabilizer

StabilCoat® Immunoassay Stabilizer increases signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.

From $34.00/EA
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SC05 - 5X StabilCoat® Immunoassay Stabilizer

5X StabilCoat® Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.

From $173.00/EA
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SG01 - StabilGuard® Immunoassay Stabilizer

StabilGuard® (protein free) Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.

From $34.00/EA
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ST01 - StabilBlock® Immunoassay Stabilizer

StabilBlock® Immunoassay Stabilizer gives assay developers the best possible tool to lower non-specific binding and maximize the signal-to-noise ratios of immunoassays.

From $36.00/EA
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