Dried Protein & Stability Blocking
Surmodics immunoassay reagents preserve the conformation and activity of dried proteins coated on a wide range of surfaces, keeping antibodies and antigens at peak performance for long durations. At the same time, the blocking mechanisms in these reagents reduce non-specific binding of interfering proteins to maximize assay sensitivity.
Our immunoassay stabilizers are the gold standard for stability and blocking efficacy. They provide improved assay performance in a one-step process for streamlined manufacturing.
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StabilZyme® HRP, StabilZyme® Protein-Free and StabilZyme® NOBLE stabilizers provide the assay developer a complete set of tools to stabilize different HRP conjugates for long term, in-solution stability.Shop Now
Boosting sensitivity. Surmodics Immunoassay Stabilizers provide a choice of blocking mechanisms to achieve optimal signal-to-noise ratios for each assay.
Low standards were run on a commercial PAPP-A sandwich assay using plates coated with StabilBlock®, StabilCoat®, StabilGuard® Immunoassay stabilizers and a competitive commercial blocker. The signal-to-noise ratios were quantified.
Surmodics Immunoassay Stabilizers demonstrated at least 85% retained activity for greater than two years with accelerated stability projectionsShop Now
Prolonging shelf life. Accelerated stability projections demonstrate at least 85% retained activity for greater than 2 years using Surmodics Immunoassay Stabilizers.
The accelerated stability tests used a rabbit polyclonal IgG ELISA assay to assess each stabilizer. 77 days of accelerated stability testing is equivalent to 2+ years of real-time stability.
DRIED PROTEIN STABILITY
StabilBlock® Immunoassay Stabilizer gives assay developers the best possible tool to lower non-specific binding and maximize the signal-to-noise ratios of assays.Shop Now
Lowering non-specific binding. StabilBlock® minimizes non-specific binding from the sample matrix and downstream assay components to enable lower detection limits.
A serum assay was constructed to demonstrate lower non-specific binding from the sample matrix. Mouse IgG was passively absorbed onto a plate and blocked. Human serum was incubated, washed and detected using an anti-human IgG (HRP) conjugate. Passive absorption of serum on the plate was quantified.
- Extended shelf life of dried proteins on various surfaces, including polystyrene plates, latex beads, magnetics particles and nitrocellulose membranes
- Increased signal-to-noise ratios across the assay range
- Multiple formulations to optimize lower detection limitsELISA/EIA, ELISpot, RIA, immunoblots and microarrays applications
- Elimination of non-specific binding from the sample matrix and other assay components
Ease of manufacture
- One-step blocking and stabilization process for shorter cycle times
- ISO 13485/9001 facility for lot-to-lot consistency
StabilCoat® Immunoassay Stabilizer increases signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
5X StabilCoat® Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
StabilGuard® (BSA free) Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
StabilGuard Choice Microarray Stabilizer (BSA-Free) improves the stability of proteins covalently bound to microspheres stored in solution and array proteins stored in the dried state, without the use of BSA protein.