Dried Protein & Stability Blocking
Gold standard
Surmodics™ immunoassay reagents preserve the conformation and activity of dried proteins coated on a wide range of surfaces, keeping antibodies and antigens at peak performance for long durations. At the same time, the blocking mechanisms in these reagents reduce non-specific binding of interfering proteins to maximize assay sensitivity.
Our immunoassay stabilizers are the gold standard for stability and blocking efficacy. They provide improved assay performance in a one-step process for streamlined manufacturing.
Shop All ProductsSignal-to-noise ratios
StabilBlock™, StabilCoat™ and StabilGuard™ (protein-free) Immunoassay Stabilizers provide alternative blocking mechanisms to achieve the best signal-to-noise ratios for each assay.
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Boosting sensitivity. Surmodics Immunoassay Stabilizers provide a choice of blocking mechanisms to achieve optimal signal-to-noise ratios for each assay.
Low standards were run on a commercial PAPP-A sandwich assay using plates coated with StabilBlock™, StabilCoat™, StabilGuard™ Immunoassay stabilizers and a competitive commercial blocker. The signal-to-noise ratios were quantified.
Shop NowSurmodics Immunoassay Stabilizers demonstrated at least 85% retained activity for greater than two years with accelerated stability projections
Learn more about how to determine protein stability
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Prolonging shelf life. Accelerated stability projections demonstrate at least 85% retained activity for greater than 2 years using Surmodics Immunoassay Stabilizers.
The accelerated stability tests used a rabbit polyclonal IgG ELISA assay to assess each stabilizer. 77 days of accelerated stability testing is equivalent to 2+ years of real-time stability.
Learn More About ELISA SubstratesDRIED PROTEIN STABILITY
Non-specific binding
StabilBlock™ Immunoassay Stabilizer gives assay developers the best possible tool to lower non-specific binding and maximize the signal-to-noise ratios of assays.
Learn more about protein stabilizers
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Lowering non-specific binding. StabilBlock™ minimizes non-specific binding from the sample matrix and downstream assay components to enable lower detection limits.
A serum assay was constructed to demonstrate lower non-specific binding from the sample matrix. Mouse IgG was passively absorbed onto a plate and blocked. Human serum was incubated, washed and detected using an anti-human IgG (HRP) conjugate. Passive absorption of serum on the plate was quantified.
Longer stability
- Extended shelf life of dried proteins on various surfaces, including polystyrene plates, latex beads, magnetics particles and nitrocellulose membranes
Increased sensitivity
- Increased signal-to-noise ratios across the assay range
- Multiple formulations to optimize lower detection limitsELISA/EIA, ELISpot, RIA, immunoblots and microarrays applications
Negligible backgrounds
- Elimination of non-specific binding from the sample matrix and other assay components
Ease of manufacture
- One-step blocking and stabilization process for shorter cycle times
- ISO 13485/9001 facility for lot-to-lot consistency
SX01 - StabilMaX™ Immunoassay Stabilizer
StabilMaX™ Immunoassay stabilizer maintains assay signal and provides stability with ample blocking capability to reduce non-specific binding, often ideal for antigen-down assays.
SC01 - StabilCoat™ Immunoassay Stabilizer
StabilCoat™ Immunoassay Stabilizer increases signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
SC02 - StabilCoat™ Plus Stabilizer
StabilCoat™ Plus microarray stabilizer improves the stability of proteins covalently bound to microspheres stored in solution and array proteins stored in the dried state.
SC05 - 5X StabilCoat™ Immunoassay Stabilizer
5X StabilCoat™ Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
SG01 - StabilGuard™ Immunoassay Stabilizer
StabilGuard™ (BSA free) Immunoassay Stabilizers increase signal-to-noise ratios of assays through effective blocking of the plate while maximizing the binding capacity of the antigen/antibody epitopes.
SG02 - StabilGuard™ Choice Stabilizer
StabilGuard™ Choice Microarray Stabilizer (BSA-Free) improves the stability of proteins covalently bound to microspheres stored in solution and array proteins stored in the dried state, without the use of BSA protein.
ST01 - StabilBlock™ Immunoassay Stabilizer
StabilBlock™ Immunoassay Stabilizer gives assay developers the best possible tool to lower non-specific binding and maximize the signal-to-noise ratios of immunoassays.
