Ku (p70/p80)

Eukaryotic Ku is a heterodimeric DNA binding protein formed by the p70 and p80 subunits that were named according to their respective molecular weight. Ku is a key factor of the non-homologous end joining (NHEJ) DNA repair pathway by directly binding to DNA ends created at DNA double strand breaks. DIARECT™ antigens are for further manufacturing or research use only.

Origin
Recombinant. Expressed by recombinant baculovirus (Autographa californica multiple nuclear polyhedrosis virus; AcMNPV) infection of Spodoptera frugiperda Sf9 insect cells.
Biochemical Test
SDS-PAGE; Western blot with i: anti-Ku autoantibody-positive sera; ii: monoclonal anti-hexa-His-tag antibody.
Calculated Molecular Weight
p70 subunit: 70,638 Dalton; p80 subunit: 83,528 Dalton
Calculated Isoelectric Point
p70 subunit: pH 6.3; p80 subunit: pH 5.7; p70/p80 heterodimer: around pH 6.0
Coating Concentration
0.2-0.6 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.  

A173


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Option Quantity Unit Purchase
Ku (p70/p80)
A17300
0.1 mg
$130.00/EA
In Stock
Ku (p70/p80)
A17301
1.0 mg
$1,505.00/EA
In Stock

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