IA-2 (ICA 512)

Insulinoma-associated protein (IA-2), also called islet cell antigen 512 (ICA 512), is a catalytically inactive protein tyrosine phosphatase (PTP)-like protein and a major target of autoimmune response in diabetes mellitus. The long C-terminal intracellular tail, harbors the majority of autoantibody epitopes. IA-2 is expressed within secretory granules in neural, neuroendocrine and pancreatic islet cells. DIARECT™ antigens are for further manufacturing or research use only.

Recombinant. Expressed by recombinant baculovirus (Autographa californica multiple nuclear polyhedrosis virus; AcMNPV) infection of Spodoptera frugiperda Sf9 insect cells.
Biochemical Test
SDS-PAGE (purity > 80%); Western-Blot with patient sample
Calculated Molecular Weight
45 kDa
Coating Concentration
pH 6.2


Option Quantity Unit Purchase
IA-2 (ICA 512)
50 µg
In Stock
IA-2 (ICA 512)
1.0 mg
In Stock

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